Tag Archives: William J. Brennan

HIV, CF, CMT, and HD in CR

The presence of organizations in the Czech Republic that cares for its citizens with human immunodeficiency virus (HIV), cystic fibrosis (CF), Charcot-Marie-Tooth (CMT), and Huntington’s Disease (HD) could only mean that the mentioned diseases are prevalent there and, therefore, should be controlled.

The human immunodeficiency virus (HIV) is a virus that attacks the immune system. Without it, our bodies would have trouble fighting off diseases. It could lead to dementia, anxiety and depression, and seizure, among others.

As such, the Bill and Melinda Gates foundation donated $140 million dollars to search for its cure. It would be similar to a pump in the form of an implant.

Cystic fibrosis (CF) is an inherited disorder that can damage the cells in the body that produce mucus, sweat and digestive juices. It can affect the respiratory system, gastrointestinal system, musculoskeletal system, genitourinary system, and the reproductive system. The disease is caused by a defect in a single gene, which scientists refer to as CFTR.

Recently, though, researchers at the Case Western Reserve University have found a way to replace the gene that causes CF with a new imaging technique.

It is called the tri-modal imaging device that consists of an x-ray, the first modality that can tell about the structure; and the gamma emission and the optical, the other two modalities that can both give information function.

Charcot-Marie-Tooth (CMT) is caused by mutations in genes that produce proteins involved in the structure and function of either the peripheral nerve axon or the myelin sheath. Once it degenerates, the motor nerves could result in muscle weakness and atrophy in the extremities (arms, legs, hands, or feet) while the sensory nerves could bring about a reduced ability to feel heat, cold, and pain.

Last October 24, 2016, though, scientists at the Washington University School of Medicine in St. Louis and Stanford University reported that they have designed small compounds with a potential to correct the mitochondrial dysfunction in CMT. “This mitochondrial protein has never been targeted before,” the senior author Gerald W. Dorn II, MD, the Philip and Sima K. Needleman Professor of Medicine was quoted saying in a report.

A progressive brain disorder, Huntington’s Disease causes uncontrolled movements, emotional problems, and loss of thinking ability (cognition). It usually happens in a person’s thirties or forties (adult-onset Huntington disease) or during childhood or adolescence (juvenile Huntington’s disease) and affects an individual’s walking, speaking, and swallowing.

Fortunately, an electric wheelchair was invented by Dr. Yodchanan Wongsawat from the Center for Biomedical and Robotics Technology Faculty of Engineering at Mahidol University in Thailand. It has an automated navigation system that can adapt on whether the hands of the user are still functional. If it is, a patient could use their hands. If it is not, the modes can be operated by one’s chin or eye.

The wheelchair can also detect obstacles on the floor with its Rotating Laser Scanner, map location with its Laser Scanner, describe commands with its 7’’ LCD screen, and acquire data with its Mini-PC.

Another device, the Eye Gaze System, can generate speech by simply looking at control keys or cells displayed on a screen. It could empower people with Huntington’s disease—particularly those in later stage—since they usually have poor muscle coordination, mental decline, and behavioral symptoms.

“Congress acknowledged that society’s accumulated myths and fears about disability and disease are as handicapping as the physical limitations that flow from actual impairment.” ~William J. Brennan, Jr.

Video taken from the YouTube Channel of the AP Archive